Warren Hurlburt Selected Research

BMS 754807

2/2015	IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines.
9/2010	Differential mechanisms of acquired resistance to insulin-like growth factor-i receptor antibody therapy or to a small-molecule inhibitor, BMS-754807, in a human rhabdomyosarcoma model.
12/2009	BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR.

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Warren Hurlburt Research Topics

Disease

4	Neoplasms (Cancer) 09/2010 - 05/2005
3	Rhabdomyosarcoma 09/2010 - 01/2009
2	Sarcoma (Soft Tissue Sarcoma) 09/2010 - 01/2009
2	Neuroblastoma 12/2009 - 01/2009
1	Colorectal Neoplasms (Colorectal Cancer) 02/2015
1	Resistance To Insulin-Like Growth Factor I 09/2010
1	Leukemia 12/2009
1	Liposarcoma 12/2009
1	Multiple Myeloma 12/2009
1	Ewing Sarcoma (Sarcoma, Ewing) 01/2009
1	Adenocarcinoma 05/2005
1	Carcinogenesis 05/2005

Drug/Important Bio-Agent (IBA)

3	BMS 754807IBA 02/2015 - 12/2009
3	IGF Type 1 Receptor (IGF 1 Receptor)IBA 09/2010 - 05/2005
2	Biomarkers (Surrogate Marker)IBA 02/2015 - 01/2009
2	Phosphotransferases (Kinase)IBA 09/2010 - 05/2005
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 09/2010
1	AntibodiesIBA 09/2010
1	Insulin ReceptorIBA 09/2010
1	4- chloro- 3',6'- dimethyl- 2,2'- iminodibenzoate (TO 115)IBA 12/2009
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 12/2009
1	Caspase 3 (Caspase-3)IBA 12/2009
1	BMS 536924IBA 01/2009
1	Insulin-Like Growth Factor I (IGF-1)IBA 05/2005
1	AS 8IBA 05/2005

Therapy/Procedure

2	Therapeutics 09/2010 - 01/2009